Palmitoylethanolamide
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Palmitoylethanolamide (PEA)
PEA is an endogenous fatty acid amide, which belongs to the class of nuclear factor agonists.
PEA has been shown to bind to nuclear receptors (NRs) and exert a large variety of related
chronic pain and inflammation biological functions. PEA also has affinity to cannabinoid like
G-coupled receptors GPR55 and GPR119. PEA has been shown to have anti-inflammatory,
analgesic action, neuroprotective, and anticonvulsant effect properties.
Description
Fine white crystal powder
CAS No.
544-31-0
Physical & Chemical Properties
Formula Molecular C18H37NO2
Weight Chemical 299.49
Specifications
• Purity (HPLC)
Not less than 99.0%
Physiological Function
• PEA is an endogenous fatty acid amide, which has been proven to
have analgesic and anti-inflammatory activity etc.
• PEA’s analgesic actions may be due to its agonism of peroxisome
proliferatoractivated receptor-α (PPAR-α) which has been shown
to have a pivotal role in the PEA pharmacodynamic mechanisms
for pain relief . PEA plays an important role in suppression of
inflammation by reducing the activity of the pro-inflammatory
enzymes such as COX, eNOS, and iNOS and by reducing mast cell
activation.
Uses
• Palmitoylethanolamide is recommended for use as a dietary
supplement ingredient.
Structure/Function Claims
• Anti-inflammatory
• Analgesic action
• Neuroprotective
• Anticonvulsant effect
Formulating Techniques
• PEA can be formed in a tablet, softgel or two-piece capsule. • It can be used as an ingredient in a single entity, multivitamin/herb
preparation.
Storage
• Store in a well-closed container away from moisture and direct
sunlight.
Packaging
• Standard packing
25Kg/Drum